Oliver Werz Selected Research

Prostaglandins

1/2024	Influenza A virus selectively elevates prostaglandin E2 formation in pro-resolving macrophages.
1/2024	Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells.
1/2024	Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening.
1/2022	Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.
11/2020	Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis.
1/2020	Differential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytes.
12/2019	15-Hydroperoxy-PGE2 : Intermediate in Mammalian and Algal Prostaglandin Biosynthesis.
8/2018	Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
1/2018	Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.
1/2017	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation.

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Oliver Werz Research Topics

Disease

100	Inflammation (Inflammations) 05/2024 - 10/2005
42	Neoplasms (Cancer) 05/2024 - 07/2006
22	Peritonitis 08/2023 - 11/2013
19	Asthma (Bronchial Asthma) 11/2022 - 03/2002
11	Infections 01/2024 - 01/2012
10	Pleurisy (Pleuritis) 01/2017 - 04/2009
9	Hypersensitivity (Allergy) 12/2023 - 08/2005
8	Atherosclerosis 01/2020 - 12/2005
7	Edema (Dropsy) 12/2022 - 04/2009
7	Pain (Aches) 01/2022 - 03/2010
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 04/2009
6	Wounds and Injuries (Trauma) 04/2024 - 12/2018
5	Carcinogenesis 07/2012 - 04/2009
4	Arthritis (Polyarthritis) 01/2021 - 10/2018
3	Tuberculosis (Tuberculoses) 01/2023 - 01/2020
3	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 09/2014
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 11/2015
3	Alzheimer Disease (Alzheimer's Disease) 02/2015 - 06/2010
2	Demyelinating Diseases (Demyelinating Disease) 01/2024 - 10/2021
2	Atopic Dermatitis (Atopic Eczema) 12/2023 - 08/2023
2	Osteoarthritis 01/2023 - 09/2008
2	Sepsis (Septicemia) 05/2021 - 01/2018
2	Rheumatoid Arthritis 01/2021 - 01/2018
2	Relapsing-Remitting Multiple Sclerosis 01/2020 - 01/2018
2	Foodborne Diseases 12/2019 - 01/2019
2	Hyperalgesia 07/2019 - 01/2017
2	Gout 10/2018 - 10/2018
2	Shock 08/2017 - 07/2011
2	Fever (Fevers) 11/2015 - 03/2011
2	Carcinoma (Carcinomatosis) 08/2009 - 05/2009

Drug/Important Bio-Agent (IBA)

42	LipidsIBA 01/2024 - 04/2008
40	LeukotrienesIBA 01/2024 - 03/2002
33	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2024 - 08/2005
21	ProstaglandinsIBA 01/2024 - 09/2008
21	ZymosanIBA 08/2023 - 11/2013
18	Dinoprostone (PGE2)FDA Link 01/2024 - 05/2009
17	EnzymesIBA 01/2022 - 07/2006
15	CarrageenanIBA 12/2022 - 04/2009
13	CytokinesIBA 01/2024 - 04/2008
13	EicosanoidsIBA 01/2024 - 01/2012
13	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2024 - 08/2009
13	Arachidonic Acid (Vitamin F)IBA 01/2024 - 01/2003
11	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2024 - 01/2020
10	Leukotriene B4IBA 10/2020 - 04/2009
9	Proteins (Proteins, Gene)FDA Link 05/2024 - 06/2012
7	LipoxygenasesIBA 01/2023 - 09/2012
7	Prostaglandins EIBA 07/2012 - 08/2009
6	FrankincenseIBA 01/2023 - 06/2014
6	AcidsIBA 10/2022 - 06/2011
5	Prostaglandin-E SynthasesIBA 11/2022 - 07/2014
5	myrtucommulone AIBA 03/2022 - 01/2015
5	Adenosine Triphosphatases (ATPase)IBA 01/2019 - 10/2014
4	Epoxide HydrolasesIBA 05/2024 - 01/2022
4	CelluloseIBA 04/2024 - 05/2020
4	CurcuminIBA 01/2022 - 08/2009
4	AndrogensIBA 01/2021 - 12/2008
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 04/2024 - 10/2021
3	GlucocorticoidsIBA 04/2024 - 01/2022
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2024 - 01/2016
3	Lipoxygenase (Lipoxygenase-1)IBA 10/2023 - 01/2019
3	AllergensIBA 01/2022 - 01/2019
3	Vitamin E FDA LinkGeneric 01/2022 - 01/2018
3	LipopolysaccharidesIBA 05/2021 - 05/2009
3	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021 - 01/2020
3	Glutathione (Reduced Glutathione)IBA 01/2021 - 01/2018
3	OxylipinsIBA 12/2019 - 12/2018
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2015 - 06/2010
2	Dinitrochlorobenzene (DNCB)IBA 12/2023 - 08/2023
2	Immunoglobulin E (IgE)IBA 12/2023 - 08/2023
2	Phospholipids (Phosphatides)FDA LinkGeneric 10/2023 - 01/2018
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2023 - 01/2023
2	Tocopherols (Tocopherol)IBA 05/2023 - 07/2021
2	boswellic acidIBA 01/2023 - 07/2021
2	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 01/2023 - 11/2021
2	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2022 - 01/2016
2	OvalbuminIBA 12/2022 - 01/2016
2	AntioxidantsIBA 12/2022 - 10/2019
2	hyperforinIBA 03/2022 - 11/2015
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2022 - 07/2019
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2022 - 06/2010
2	Glycogen Synthase KinasesIBA 10/2020 - 05/2014
2	ResveratrolIBA 10/2019 - 11/2014
2	Analgesics (Analgesic Drugs)IBA 07/2019 - 01/2017
2	LignansIBA 01/2019 - 08/2011
2	MK-886IBA 08/2017 - 04/2009
2	Platelet Activating FactorIBA 08/2017 - 07/2011
2	Protons (Proton)IBA 01/2017 - 10/2014
2	Proton-Translocating ATPases (ATPase, H+)IBA 01/2017 - 10/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 04/2009
2	Peroxidase (Myeloperoxidase)IBA 04/2016 - 04/2009
2	Cytochromes c (Cytochrome c)IBA 11/2015 - 01/2008
2	Interleukin-6 (Interleukin 6)IBA 08/2015 - 10/2014
2	pretubulysinIBA 08/2014 - 03/2014
2	Therapeutic UsesIBA 06/2012 - 10/2005
2	Prostaglandin H2 (PGH(2))IBA 03/2011 - 08/2009
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 12/2006 - 03/2002

Therapy/Procedure

12	Therapeutics 01/2022 - 03/2002
8	Drug Therapy (Chemotherapy) 01/2023 - 01/2017
4	Traditional Medicine (Folk Remedies) 03/2022 - 01/2012
2	Oral Administration 01/2022 - 01/2018